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Avogadro - Avogadro is a free, fantastically easy to use molecule editor.
ChemDraw - ChemDraw - The Gold Standard for Chemical Structure Drawing and Research Publications.
ACD/ChemSketch - ACD/ChemSketch for personal and academic use brings the power of our structure drawing package to your home computer.
Periodic-table.io - Interactive periodic table of the chemical elements in 38 languages - Includes properties, history, name origin, facts, applications, hazards, isotopes and more
BKchem - BKChem is a free (as in free software :o) chemical drawing program.
SketchBook - SketchBook is a professional drawing or painting application that allows designers, architects, and concept artist to sketch their ideas and create adorable illustrations in no time.