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Live2D Cubism - Live2D is the world's first drawing technology to enable 3D rendering of 2D images.
Jpixel - JPixel is an editor for making pixel art animations and tilesets.
AnimeEffects - AnimeEffects is a 2D keyframe animation tool based on deformation of polygon meshes.
Synfig Studio - Just another WordPress site
DragonBones - DragonBones is an open source project for 2D skeletal animation.
Spine - Spine is 2D animation software designed specifically for software and game development.